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Contraindications: Hypersensitivity Side Effects: CNS Depression (Sedation) & Bradycardia : The most common adverse effects of clonidine are sedation, dry mouth (xerostomia) , fatigue , bradycardia , dizziness, and constipation (Patel and Saadabadi, 2025

[5] Mechanistic data indicate PAT inhibits NF-B nuclear translocation, the transcription factor governing proinflammatory cytokine and COX-2 gene expression

11 Interestingly, the majority of patients in the European study who were positive for HLA-B*1502 and developed carbamazepine-induced SJS/TEN were of Southeast Asian descent